Endocrine Abstracts

Chronic hypoparathyroidism (HypoPT) is a rare endocrine condition characterised by hypocalcaemia and deficient or absent parathyroid hormone. The recent European Society of Endocrinology Guidelines outline recommendations for treatment and monitoring of chronic HypoPT in adults. A Delphi panel was conducted to agree upon the characteristics that define ‘not adequately controlled on standard therapy’ where this relates to patients with chronic H...

Background: We would like to present a case of pancreatic encephalopathy induced by DKA induced hypertriglyceridemia. The triad of acute pancreatitis, hypertriglyceridemia and diabetes is a rare occurrence. Through our case we aim to highlight the importance of making an early diagnosis as a delay in diagnosis can worsen outcomes.Case history: We present the case of a 51 year old Type 2 Diabetic non compliant with her medications who was admitted to the ...

Introduction: There were concerns voiced by health care professionals (HCPs) that restrictions to healthcare delivery during the pandemic has resulted in delays in diagnosing T1D in CYP. Most CYP present with symptoms of T1D to primary care. Delay in diagnosis increases the risk of potentially life-threatening diabetic ketoacidosis (DKA). In Cardiff, we piloted QI initiatives pre-pandemic to improve early diagnosis which was introduced across the Children and Young People&#146...

Background: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycaemic state (HHS) are common diabetic emergencies. However, the associated morbidity and mortality remains substantial. Non-specialist trainee healthcare professionals (HCPs) are usually the first point of contact in managing these patients in the acute medical setting. It is therefore essential that these trainees are confident in the management of these emergencies. Aims: Our aim was to ...

Background: Adrenal crisis is a potentially life-threatening situation which can affect any patient with adrenal insufficiency (AI). Patients with AI and healthcare professionals looking after them should know the sick day rules and when and how to use parenteral hydrocortisone. Patient stories and feedback from patients with AI indicated low standards locally. We therefore aimed to empower patients through education and provide them with a hydrocortisone emergency kit.<p ...

Case history: Thyrotoxic periodic paralysis (TPP) which was first described in 1902 is characterised by episodes of painless muscle weakness, hypokalaemia and thyrotoxicosis without any total body potassium deficit. It predominantly affects people of Asian descent between 20 and 40 years old with a 2 percent incidence compared to 0.2 percent in non-Asian descent. The pathogenesis of TPP is related to an increase Na+/K+-ATPase activity in the skeletal muscle leading to an influ...

Background: Biochemical biomarker DT is used clinically for prognosis prediction in several solid malignancies. The aim of the current analysis was to determine whether biomarker DT has any prognostic utility in patients with NETs.Methods: Patients with NETs (n=184) were enrolled in a prospective study with comprehensive biochemical analysis. The current analysis included subjects with increasing 5-HIAA levels in at least two consecutive measure...

Background: Accurate diagnosis of an underlying cause of thyrotoxicosis is critical for targeted therapy. Thyroid radionuclide uptake scan is a useful second line investigation in patients who lack TSH receptor antibody. The uptake scan patterns identify patients who can be preferentially treated with anti-thyroid drugs (diffuse pattern - Graves’ disease) or radio-iodine treatment (patchy uptake - multinodular or localised uptake – toxic adenoma) or simple monitoring...

Background: Cerebral palsy (CP) is the most common physically disabling childhood motor disorder. Fractures in this group of children are common, however, prevalence and risk factors associated with fractures in children with CP in the UK is not known.Aims: The aims of this cross-sectional survey were i) to determine the prevalence of fractures in children with moderate-to-severe CP in Manchester, ii) to determine the common sites of fracture, and iii) t...

Introduction: Approximately 700 000 women give birth in England and Wales each year with up to 5% of these women having either pre-existing diabetes or gestational diabetes (GDM). Women who have diabetes during pregnancy, it is estimated that approximately 87% have GDM. It is well recognised that early diagnosis of diabetes aids in timely intervention to reduce long-term complications.Objectives: To assess the screening for diabetes mellitus in post-deli...